Help. I'm lost and don't know what to do?

At 48 I feel like I've given up. I'm overweight, I'm not working because of back/hip issues, my house is a disaster, filled with clutter and unfinished projects, my daughter just moved out of state and I miss her, my husband works, sleeps and eats--never time or energy for anything fun--and I spend my time either taking care of my elderly parents, on the computer or sleeping. On top of it all I feel like a huge failure. I spent my teens, 20's, 30's blazing new paths. If I wanted it-I chased it. I had wonderful jobs, travelled extensively, great homes, my own business, great kids and more. There were ups and downs, but always ideas, energy and life. Last decade not so much. My feet are in glue. I've done the antidepressants, therapy and such. It's only 7:30 PM here and I feel like I should just go to bed. Just me and the elephant on my chest.